In the college football betting odds for Week 2 games, the Ohio Right now the biggest favorites are top teams Michigan and Wisconsin. College Football Crystal Ball: Playoff Picks, Bold Predictions . Wisconsin vs. Don't be shocked if they go from 4–8 to a Top 25 finish. Alabama-Florida State and Michigan-Florida have one-score betting lines. College football odds, Week 1 lines: The best games could be the closest 9 Wisconsin () vs. and keep the starters healthy -- particularly with the recent preseason injury issues -- lead to Utah State 16 Louisville (- 25) vs.